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  • Vern Morgan posted an update 3 days, 23 hours ago

    Rmany Vital Care 2007, 11(Suppl two):P208 (doi: 10.1186/cc5368) Introduction Nebulization of pulmonary surfactant for treatment of ARDS represents a desirable therapeutic method but was hitherto not possible below clinical conditions because of the technical limitations of at present available devices. Within the present study we investigated a new dry powder nebulizer for administration of a recombinant surfactant protein C (rSP-C)-based surfactant. Techniques The nebulizer device consists of a cylindrical glass housing that, in the bottom, ends up within a spherical decrease housing aspect that serves as the dry powder reservoir. A gas inlet portion using a nozzle at its finish is coaxially aligned together with the housing, virtually reaches the bottom on the dry powder reservoir, and induces aerosol generation when gas pressures among 1 and two bar are applied. The upper portion of your housing contains a cap with an aerosol exit port. Quite a few nozzles make sure a discharge of unsuitably massive aerosol particles. Aerosol traits were determined by laser diffractometry. The efficacy of an inhalative rSP-C surfactant application was assessed in 3 animal models of acute lung injury, like rabbits with acute lung injury because of either repetitive lavage with prolonged and injurious ventilation, or resulting from inhalative application of bleomycin at day four, and bleomycinchallenged, spontaneously breathing mice. Results The generated aerosol had a mass median aerodynamic diameter of 1.6 , with 85 of all particles getting smaller thanP207 Pulmonary expansion and disobstruction maneuver using a closed program in patients with acute lung injury and acute distress syndrome, and its effect on gas exchangeJ Belato, S Barreto, C Santos, S Vieira Hospital de Cl icas de Porto Alegre, Brazil Vital Care 2007, 11(Suppl two):P207 (doi: ten.1186/cc5367) Introduction Respiratory physiotherapy is ever extra utilized for the remedy of essential patients. On the other hand, it is actually identified that there areSCritical CareMarch 2007 Vol 11 Suppl27th International Symposium on Intensive Care and Emergency Medicine5 , and also the average mass of surfactant becoming nebulized under these circumstances was roughly 1 g/min. Biochemical and biophysical studies showed that the composition and surface tension lowering properties with the rSP-C surfactant remained unaltered after nebulization. In each rabbit models, administration of 130 mg/kg body weight rSP-C surfactant resulted inside a far-reaching restoration of gas exchange and compliance. In bleomycinchallenged, spontaneously breathing mice, surfactant aerosolization resulted within a restoration of compliance. Conclusions Nebulizer qualities and outcomes from the in vivo studies suggest that the herein-described dry powder nebulizer may NS-75A cost possibly proffer for surfactant therapy of ARDS.P209 Adjustments in respiratory mechanics soon after fiberoptic bronchoscopy with bronchoalveolar lavage in mechanically ventilated patients?Estella Garc , A Gil Cano, J D z Monrove, I Monge Garc Crucial Care Unit, Hospital of Jerez, Spain Crucial Care 2007, 11(Suppl 2):P209 (doi: 10.1186/cc5369) Introduction Nonuniform findings have already been reported in regards to the effects of bronchoalveolar lavage (BAL) on respiratory mechanics. Objectives (1) To study the effects of BAL on respiratory mechanics in mechanically ventilated patients with suspected pneumonia, and (two) to discover irrespective of whether these effects are related to the extension of radiographic infiltrate and preceding respiratory mechanics measurements. Techniques.