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Considered significant. Discrimination of the classifications was assessed by the area under the receiver CFI-400945 (fumarate) biological activity operator characteristic curve (AuROC). Calibration was assessed by the Hosmer emeshow (HL) goodness-of-fit test. Data were computed on SPSS 11.5, Win-XP compatible. Results and discussion Differences between Group I and Group II were statistically significant concerning obstetric hemorrhagic complication (P < 0.001), incidence of acute renal failure (P = 0.01), mortality (P = 0.001), LOS (6.5 ?7 days vs 4.4 ?4 days, P = 0.001), SAPS-Obst score (24.5 ?8 vs 16.8 ?7, P < 0.001). The Mississippi classification discriminated well, but calibrated badly. In contrary, the Tennessee classification was a poor discriminator but calibrated very well. See Table 1.P384 Stroke and pregnancy: etiology, timing and outcomeR Souissi, W Trabelsi, Z Haddad, M Boubaker, M Lamourou, K Baccar, C Kaddour, L Skandrani National Institute of Neurology, Tunis, Tunisia Critical Care 2007, 11(Suppl 2):P384 (doi: 10.1186/cc5544) Background and goal Most previous studies on stroke during pregnancy have mainly focused on incidence and risk factors. These studies have not reported details of etiology and stroke outcome. The present study focuses on the evaluation of the etiology, timing and outcome of stroke occurring during pregnancy. Materials and methods We conducted a retrospective analysis on all obstetric patients who have been diagnosed with stroke during pregnancy or within 8 weeks postpartum. These patients were transferred to our multidisciplinary ICU between January 1996 and December 2004. All patients were investigated with a CT scan of the brain, and MRI and/or cerebral angiography. Results Eighty-eight patients were included, 34 of them were excluded (incomplete investigations or nonstroke diagnosis: reversible leucoencephalopathy, cerebral abscess, etc.). Fifty-four patients with a diagnosis of stroke were identified: 30 patients with ischemic stroke (IS) and 24 patients with hemorrhagic stroke (HS). The majority of events (45 patients, 83 ) occurred in the third trimester and postpartum period (P = 0.02). A specific cause was identified in 24 patients (80 ) of IS and in 21 patients (87 ) of HS. Causes of IS include preeclampsia/eclampsia in 11 patients, venous thrombosis and coagulopathies (deficiencies of protein C, protein S, and activated protein C resistance) in nine patients, valvular heart disease with history of prior stroke in four patients and six patients had no definable cause. The major causes of HS were preeclampsia/eclampsia in eight patients, four patients presented with hemorrhage secondary to aneurysmal rupture, three patients presented with bleeding from arterio-venous malformations (AVM), bleeding as a consequence of disseminated intravascular coagulation (DIC) occurred in two patients and seven patients had hemorrhagic events of unknown origin. Hypertensive disorders of pregnancy were the most common comorbid conditions (32 ). Nineteen deaths (35 ) occurred in our study, eight patients with infarction and 11 patients with hemorrhage. Thirty-one patients left the hospital with neurologic deficits, requiring chronic care or rehabilitation. Discussion and conclusion The results of the present study complement the findings of previous studies on timing of stroke in pregnancy [1,2]. We found that preeclampsia/eclampsia and intracranial vascular malformations were the major causes of stroke in pregnancy, which agrees with other findings.